IN VITRO ASSESSMENT OF THE ANTHELMINTIC ACTIVITY OF COPPER OXIDE AND ZINC OXIDE NANOPARTICLES ON EGG AND ADULT STAGES OF FASCIOLA HEPATICA: EVIDENCE ON OXIDATIVE STRESS BIOMARKERS, AND DNA DAMAGE

In vitro assessment of the anthelmintic activity of copper oxide and zinc oxide nanoparticles on egg and adult stages of Fasciola hepatica: evidence on oxidative stress biomarkers, and DNA damage

Abstract Objectives Fasciolosis is of significant economic and public health importance worldwide.The lack of a successful vaccine and emerging resistance in flukes to the drug of choice, triclabendazole, has initiated the search for alternative approaches.In recent years, metallic nanoparticles have been extensively investigated for their anthelmi

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Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury.

Failure of central nervous system (CNS) axons to regenerate after injury results in permanent disability.Several molecular neuro-protective and neuro-regenerative strategies have been proposed as potential treatments but do not provide the directional cues needed to direct target-specific axon regeneration.Here, we demonstrate that applying an exte

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